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Although mtDNA is more prone to mutations than nuclear DNA (nDNA) due to its proximity to ROS and lack of histone protection, mitochondrial nucleoid DNA-binding proteins afford some defense, with evidence suggesting these proteins can protect mtDNA from X-ray radiation and hydrogen peroxide, akin to histones ( mtDNA is implicated in the onset and progression of COPD

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Science from the early 20 th century was clear: smoking was linked to lung cancer th century was clear: smoking was linked to lung cancer Before the widespread availability of cigarettes, lung cancer was once a very rare condition